Uncontrolled cell growth in tumors leads to the formation of hypoxic regions—regions with low oxygen concentrations due to lack of access to the blood supply. Cells under hypoxia undergo changes that increase malignant characteristics and resistance to treatment. Many of these changes are controlled by HIF-1, which is controlled in an oxygen-dependent manner itself. This infographic was created to summarize a major pathway through which HIF-1 is regulated in the context of cancer hypoxia.
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